Regimen 6 showed a great increase in the frequency of CD3+ and CD8+ T cells within the tumors and was themost efficacious in restoring the immunoactive state of the TME (Figure S18).10,35 Tumor sections(H&E) obtained from mice treated with NIE-NPs revealed a markeddecrease in Ki-67 expression, an increasein CD8+ T cells, and a decrease in Foxp3 (Treg cells), compared with other control groups. Here, CD8A is linked to neoplasm.