Transcripts from 16 HCC driver genes (ALB, APOB, ASH1L, CDKN2A, CPS1, CTNNB1, DHX9, IDH1, IL6ST, NCOR1, NFE2L2, NRAS, NSMCE2, NUP133, SETDB1, and XPO1) were significantly differentiated (S6 Data) [4,41,42]. The gene discussed is NSMCE2; the disease is hepatocellular carcinoma.