DCM genes encode proteins involved in contractility (titin; TTN, troponin T; TNNT2, troponin C; TNNC1, tropomyosin; TPM1, and filamin C; FLNC), that regulate cardiac splicing (RNA-binding motif protein; RBM20) or calcium sequestration (phospholamban; PLN), and maintain cytoskeletal (desmin; DES) or nuclear (lamin A/C; LMNA) integrity. Here, TTN is linked to familial dilated cardiomyopathy.