PKP2 and familial dilated cardiomyopathy: Interestingly, upregulated genes in EC7 from DCM LVs and PKP2 RVs (Fig. 3G) encoded secreted proteins involved in myocardial stress-adaptation (NRG1) (48), CM force production (EDN1) (49, 50), and endocardial expansion during development or after cardiac injury (BMP6) (51, 52).