Thirty-eight independent PVs were identified in three DCM genes (LMNA; n=12, RMB20; n=8, TTN; n=12) and in the ACM gene PKP2 (n=6), while no PVs were detected in eight DCM patients (PVneg) (Fig. 1B). Here, TTN is linked to familial dilated cardiomyopathy.