Interestingly, upregulated genes in EC7 from DCM LVs and PKP2 RVs (Fig. 3G) encoded secreted proteins involved in myocardial stress-adaptation (NRG1) (48), CM force production (EDN1) (49, 50), and endocardial expansion during development or after cardiac injury (BMP6) (51, 52). This evidence concerns the gene EDN1 and familial dilated cardiomyopathy.