The heat map of the immune mediator expression levels demonstrated that in both groups, pro-(IFN-γ, IL-15, IL-6, IL-17a and IL-18), anti-(IL-1ra and IL-10) inflammatory cytokines, and chemokine (MCP-1) reached the highest levels during peak bacteremia (Fig 9); for the Gilliam bacteremia (3 to 12 dpi, peak at 6 dpi), and for Karp bacteremia (6 to 15 dpi, peak at 12 dpi), respectively. This evidence concerns the gene IL18 and bacterial infectious disease with sepsis.