There was no report on the effect of C3aR on type I IFNs in their 2013 report; however, a follow-up study from this lab showed that treatment of primary BMDCs with C3a followed by challenge with cyclic-di-AMP or infection with LM resulted in decreased expression and production of the type I IFN, IFNβ [9]. The gene discussed is C3AR1; the disease is infection.