Diabetes was precipitated by anti–PD-L1 but not anti–CTLA-4 mAb treatment in 7-week-old NOD mice, consistent with our clinical experience of the selectivity of CPI-DM following PD-1 pathway blockade and previous studies on PD-1 blockade in the model (Figure 3A) (37). The gene discussed is CD274; the disease is diabetes mellitus.