To investigate the direct impact of cancer cell–derived miR-155 on tumor progression and tumor immune infiltration, we established a B cell integration cluster (Bic, miR-155 gene) overexpressing breast cancer cell lines (EO771-Bic, 4T1-Bic, and AT-3-Bic) via lentiviral transduction. The gene discussed is MIR155HG; the disease is breast carcinoma.