SOCS1 and neoplasm: We found markedly reduced SOCS1 levels accompanied by increased p-STAT1 and STAT1, decreased p-STAT3, and thus an increased p-STAT1/p-STAT3 ratio in miR-155–overexpressing EO771, 4T1, and AT-3 tumor cells compared with control cells (Figure 5, I–K, and Supplemental Figure 11, A–C).