Male patients (especially when compared with female patients) and patients from NYHA class III, with diabetes, with chronic obstructive pulmonary disease, not on β-blocker medication, not on angiotensin-converting enzyme medication, with a history of myocardial infarction, and with a history of chronic atrial fibrillation showed a considerable decrease in QALYs for both HTM+DA and usual care. The gene discussed is ACE; the disease is diabetes mellitus.