The two populations of psoriasis-associated mDCS, which are suggested to originate from precursors in circulation, upon activation produce IL-23, TNFα, IL-6, and IL-12 driving differentiation of T cells toward a Th17 and/or Th1 phenotype, and also present antigens to T cells establishing structures in the dermis that resemble lymphoid tissue [23, 24]. Here, TNF is linked to psoriasis.