As shown in Fig. 5A, overexpression of Parkin or AS-IV delivery significantly downregulated p16, p21, and DcR2 in BLM-induced VSMCs, while, knockdown of Parkin reversed the suppression of p16, p21, and DcR2 by AS-IV (Fig. 5A). The gene discussed is PRKN; the disease is Bloom syndrome.