Namely, while HAdV26 binding in A549-shCLTC and A549-shCAV1 clones which have increased expression of αvβ3 integrin was comparable (Fig. S2 in the supplemental material), transduction efficiency in A549-shCLTC clones was accordingly increased (Fig. 2G), but in A549-shCAV1 clones (Fig. 5G) was not in the same line as binding, leading us to hypothesize that αvβ3 integrin mediated HAdV26 infection is caveolin-1-dependent. The gene discussed is CAV1; the disease is infection.