PPME1 and nervous system disorder: While LCMT-1 is highly abundant in cells under normal conditions (Stanevich et al., 2011), elevated PME-1 level is associated with many types of cancer (Kaur et al., 2016; Wandzioch et al., 2014) and neurological disorders (Nicholls et al., 2016; Ortega-Gutiérrez et al., 2008; Sontag et al., 2010).