CRP and major depressive disorder: These two surrogate immunometabolism markers significantly predicted all future depression nodes: (a) CRP (higher CRP → greater depressed mood: d = 1.072; higher CRP → greater somatic symptoms: d = 1.812; higher CRP → greater interpersonal problems: d = 2.112) (all ps < 0.001); and (b) HDL (higher HDL → stronger depressed mood: d = 0.196; higher HDL → stronger somatic symptoms: d = 0.162; higher HDL → stronger interpersonal problems: d = 0.134) (all ps < 0.001).