Moreover, DM ranks among the top causesof premature death and was responsible for 6.7 million deaths in 2021.It is also estimated that 541 million adults suffer from impairedglucose tolerance (IGT), a condition which places them at high riskto develop type 2 diabetes (T2DM).1,2 More than 90%of diabetic patients suffer from this latter type of DM, which ismainly related to the resistance of the target organs to insulin and,over time, also to a progressive reduction in the ability of βcells to produce insulin, with a partial deficiency in the amountof available hormone. The gene discussed is INS; the disease is type 2 diabetes mellitus.