In diabetic animal models,highly increased expression of renal SGLT-2 was observed comparedwith normal controls; moreover, in proximal tubular cells isolatedfrom T2DM patients, both SGLT-2 levels and glucose reabsorption werefound to be considerably higher than in controls, suggesting thata possible hyperglycemia-induced overexpression of glucose transporterscontributes to exacerbate the hyperglycemic condition typical of DM.3,4. The gene discussed is SLC5A2; the disease is diabetes mellitus.