SLC5A2 and Hypoglycemia: Inaddition, mutations in the SLC5A2 gene, which encodesSGLT-2 subtype, cause a condition known as familial renal glycosuria,which is associated with urinary glucose excretion (UGE), polyuria,polydipsia, and increased urinary tract infections; however, mostaffected individuals do not exhibit relevant clinical symptoms orserious complications, such as hypoglycemia, and therefore this raredisease is considered benign.16,24