Several mechanisms of cardiorenal protection due to SGLT-2inhibitionwere proposed.6,11,34−36 As reported above, the improvement of obesity/overweight,mostly the reduction of abdominal fat, leads to enhanced tissue sensitivityto insulin, counteracting the insulin resistance typical of T2DM,and results in an improvement of lipidemic profile. The gene discussed is INS; the disease is type 2 diabetes mellitus.