Thecapacity to prevent episodes of hypoglycemia, which is an importantshared characteristic of SGLT-2 inhibitors, was rationalized consideringthat SGLT-2 inhibition causes UGE only in the presence of hyperglycemia,when filtered glucose exceeds TmG, and the reabsorption process issaturated; under these conditions, SGLT-2 inhibitors are capable oflowering TmG and further promoting glucose excretion. The gene discussed is SLC5A2; the disease is Hyperglycemia.