SLC5A2 and type 2 diabetes mellitus: Finally,an aspect that attracted the interest of researchers toward this newantidiabetic agents was the almost exclusive expression and highlyspecialized function of SGLT-2 in the proximal tract of the renaltubule; consequently, highly selective inhibitors of this cotransporterwere expected to not produce adverse effects on other cellular functions.Although SGLT-2 inhibitors are generally well tolerated, it was suggestedthat certain side effects, such as genitourinary tract infections,dehydration, potential increased risk of ketoacidosis, should be closelymonitored.