INS and obesity due to melanocortin 4 receptor deficiency: Several mechanisms of cardiorenal protection due to SGLT-2inhibitionwere proposed.6,11,34−36 As reported above, the improvement of obesity/overweight,mostly the reduction of abdominal fat, leads to enhanced tissue sensitivityto insulin, counteracting the insulin resistance typical of T2DM,and results in an improvement of lipidemic profile.