Finally,an aspect that attracted the interest of researchers toward this newantidiabetic agents was the almost exclusive expression and highlyspecialized function of SGLT-2 in the proximal tract of the renaltubule; consequently, highly selective inhibitors of this cotransporterwere expected to not produce adverse effects on other cellular functions.Although SGLT-2 inhibitors are generally well tolerated, it was suggestedthat certain side effects, such as genitourinary tract infections,dehydration, potential increased risk of ketoacidosis, should be closelymonitored. This evidence concerns the gene SLC5A2 and diabetes mellitus.