On the contrary,when glycemia is normalized, TmG exceeds filtered glucose amount,even in the presence of partial SGLT-2 inhibition, and, therefore,SGLT-2 inhibitors induce neither glucosuria nor hypoglycemia.50,52 The ability to reduce glycemic levels without inducing hypoglycemia,which a serious side effect of certain other glucose-lowering agents,is an attractive feature of all SGLT-2 inhibitors, which has greatlycontributed to their development as new antidiabetic drugs. The gene discussed is SLC5A2; the disease is Hypoglycemia.