In DKK1‐overexpressing Nicd/Akt‐driven iCCA we found an increase in the proportion of F4/80‐positive cells from 10.5% in control tumours (n = 832), to 15.58% in tumours that overexpressed DKK1 (n = 401) (p < .0001) (Figure 2A and B). This evidence concerns the gene DKK1 and neoplasm.