Singer group also found that the number and Foxp3 expression, activation state, suppressive phenotype, and proliferative capacity of CD4+CD25+Foxp3+Tregs in lung enhanced in mice treated by DNA methyltransferase inhibitor indicated that epigenetic pathways are very likely to be novel targets for the treatment of ARDS.75 The gene discussed is FOXP3; the disease is acute respiratory distress syndrome.