The main mechanisms of CD4+CD25+Foxp3+Tregs in alveolar to improve ALI resolution are mediated by inducing neutrophil apoptosis and suppression of macrophage anti‐inflammatory cytokine secretion8, 72; control fibrocyte recruitment to lung to inhibit the fibroproliferation though CXCL12‐CXCR4 axis73; CD73‐dependent adenosine generation.74 The gene discussed is CD4; the disease is acute respiratory distress syndrome.