SIRT3 and heart failure: The inhibitory effect of PDH acetylation in diastolic dysfunction described here is consistent with its role in mouse models of heart failure with reduced ejection fraction (HFrEF), where miR‐195‐mediated downregulation of the deacetylase SIRT3 leads to increased acetylation of PDH subunits, decreased PDH enzymatic activity, and systolic dysfunction (Zhang et al., 2018).