Potential risk factors that were identified included non-malignant lymphoproliferative disorders, lymphadenopathy, autoimmune cytopenia, enteropathy, altered IgM levels, older age at CVID diagnosis, sex, late-onset combined immunodeficiency, germline genetic mutations (i.e. CTLA4, PI3KR1/PI3KCD, LRBA), and Epstein-Barr virus susceptibility. Here, CTLA4 is linked to Abnormal intestine morphology.