A meta-analysis of nine studies that compared demographic, clinical and immunologic characteristics between CVID patients with (n=26) or without (n=161) malignancy, found that patients with malignancy were significantly older, had higher levels of IgG, IgA and IgM (although actual levels were lower than normal), and higher frequencies of autoimmunity and malabsorption (16). Here, CD40LG is linked to cancer.