In several clinical trials involving patients with T1DM or T2DM, it was confirmed that serum MBL levels were significantly higher in patients with DKD than those DM patients without renal lesions and that high baseline MBL along with CRP levels could be used as a predictor for the development of proteinuria in DM patients (39, 42, 43). Here, MBL2 is linked to diabetic kidney disease.