The marked expression pattern of lung BRMs was the downregulation of Ccr7, Sell, S1pr1, and Klf2, and upregulation of Cxcr3, Ccr6, Ccr1, and Cd69. In addition, BRMs in a pneumococcal pneumonia model upregulated CD11a and CD44 but downregulated CD62L, a phenotype similar to that of lung CD4 TRM cells (53, 54). Here, SELL is linked to pneumococcal pneumonia.