After multivariate Cox regression analysis, eight genes were identified as key predictors of HLA-G-driven DEGs in the prognostic risk model for predicting the overall survival of patients with cervical cancer, including CD46, LGALS9, PGM1, SPRY4, CACNB3, PLIN2, MSMO1, and DAGLB. Here, SPRY4 is linked to cervical carcinoma.