After multivariate Cox regression analysis, eight genes were identified as key predictors of HLA-G-driven DEGs in the prognostic risk model for predicting the overall survival of patients with cervical cancer, including CD46, LGALS9, PGM1, SPRY4, CACNB3, PLIN2, MSMO1, and DAGLB. This evidence concerns the gene CD46 and cervical cancer.