After multivariate Cox regression analysis, eight genes were identified as key predictors of HLA-G-driven DEGs in the prognostic risk model for predicting the overall survival of patients with cervical cancer, including CD46, LGALS9, PGM1, SPRY4, CACNB3, PLIN2, MSMO1, and DAGLB. The gene discussed is SPRY4; the disease is cervical cancer.