BRCA1 and Fanconi anemia: For mPC, the Philadelphia 2019 consensus (18) recommends large panels and somatic testing; the genes considered were BRCA1/2, HOXB13, CHEK2, ATM, NBN, MSH2, MSH6, MLH1, PMS2, BRIP1, TP53 and the Fanconi anemia genes.