As part of this study, we developed and validated a stable and effective prognostic gene model based on 10 genes (SLC39A14, AACS, ERP29, LAMP3, TMEM106C, TMED2, SLC25A3, CNPY2, GRB10, and PBK) that have prognostic properties to evaluate the prognostic risk factors of CRC patients. This evidence concerns the gene ERP29 and colorectal carcinoma.