As part of this study, we developed and validated a stable and effective prognostic gene model based on 10 genes (SLC39A14, AACS, ERP29, LAMP3, TMEM106C, TMED2, SLC25A3, CNPY2, GRB10, and PBK) that have prognostic properties to evaluate the prognostic risk factors of CRC patients. The gene discussed is GRB10; the disease is colorectal carcinoma.