Human osteoarthritis chondrocytes can be inhibited by senegenin by inhibiting PI3K/AKT/NF-κB signaling pathway, inhibiting the expression of MMP-1, MMP-3, and MMP-13 induced by IL-1β, and the production of NO and PGE2 was reduced in human osteoarthritis chondrocytes. This evidence concerns the gene MMP13 and osteoarthritis.