At the same time, Senegenin in the treatment of postoperative and cognitive dysfunction, as well as ischemia-reperfusion injuries is associated with the regulation of JNK signaling pathway, the inhibition of NADPH oxidase and caspase-3 activity, the increase of Bcl-2/Bax (Zhang et al., 2016). This evidence concerns the gene MAPK8 and ischemia reperfusion injury.