In order to prevent the accumulation of ineffective proteins from causing cell damage or death, more than 85% of the proteins in eukaryotic cells are mainly degraded through the UPP (ubiquitin-proteasome pathway) (Golab et al., 2004).The degree of UPP dysfunction is significantly correlated with the accumulation of highly phosphorylated microtubule-associated protein tau (Tau) and Aβ in the AD brain (Song and Jung, 2004). Here, MAPT is linked to Alzheimer disease.