FN1 and renal fibrosis: In addition to improving the glomerular filtration function, QTR could also inhibit the accumulation of ECM by reducing the expressions of Col IV, fibronectin, and laminin in kidney tissues and downregulate the expression of renal fibrosis-related proteins α-SMA and vimentin, thus playing an antifibrosis role (Wu et al., 2008; Ma et al., 2019).