Interestingly, poricoic acid A and melatonin could upregulate growth arrest-specific 6 (Gas6)/Axl signaling to reduce oxidative stress and inflammation in the AKI disease status and further downregulate Gas6/Axl signaling to attenuate renal fibrosis in the CKD disease status (Chen D. Q. et al., 2019b). Here, AXL is linked to chronic kidney disease.