Here, due to the reduced renal filtration function in CKD, a large number of potentially nephrotoxic components (such as complement factors, growth factors, and others) are abnormally filtered into the urine, causing these macromolecules to damage the tubulointerstitium, and these substances induce renal interstitial damage far more serious than that of urine albumin (Cravedi and Remuzzi, 2013). Here, ALB is linked to chronic kidney disease.