Inhibition of the TGF-β/Smad, Wnt/β-catenin, and NF-κB/Nrf2 pathways may be the mechanisms of poricoic acid A against renal fibrosis (Chen D. Q. et al., 2019a; Chen D. Q. et al., 2019b). This evidence concerns the gene TGFB1 and renal fibrosis.