Moreover, in PCOS, there is imbalance of all the hormones, such as gonadotropin-releasing hormone (GnRH), insulin, the luteinizing/follicle-stimulating hormone (LH/FSH) ratio, androgens, estrogens, growth hormones (GHs), cortisol, parathyroid hormone (PTH), and calcitonin, and all of these hormones are involved in bone metabolism and their imbalance may enhance osteoporosis. This evidence concerns the gene GNRH1 and polycystic ovary syndrome.