PLOD1 and polycystic ovary syndrome: Moreover, in PCOS, there is imbalance of all the hormones, such as gonadotropin-releasing hormone (GnRH), insulin, the luteinizing/follicle-stimulating hormone (LH/FSH) ratio, androgens, estrogens, growth hormones (GHs), cortisol, parathyroid hormone (PTH), and calcitonin, and all of these hormones are involved in bone metabolism and their imbalance may enhance osteoporosis.