Moreover, in vivo knockdown of NPC1L1 has been shown to reduce plasma lipid levels, inflammatory cell infiltrating lymphadenectasis, and colitis-associated colorectal tumors by reducing the expression of pro-inflammatory markers, including phosphorylated c-Jun (p-c-Jun), phosphorylated extra-cellular signal-regulated kinase (p-ERK), and Caspase-1 p20 (He et al., 2015). Here, JUN is linked to colorectal neoplasm.