This work further investigates the role of hypercholesterolemia in UBC progression, and suggests that the increase of plasma ox-LDL is related to hypercholesterolemia and UBC progression, and promotes cancer stem cells via scavenger receptor B2 (CD36)/janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) axis (Yang et al., 2021). Here, JAK2 is linked to Hypercholesterolemia.