AKT1 and neoplasm: Zhang et al. report that ezetimibe drives serum cholesterol-lowering, promotes antitumor immunity and extenuates prostate tumor growth and metastasis by suppressing protein kinase B (Akt) phosphorylation and mammalian target of rapamycin complex 2 (mTORC2) signaling in lymphocytes, and by enhancing CD8+ lymphocytes memory function and tumor infiltration (Wang et al., 2022).