HSPG2 and cancer: The analysis of differential metabolic pathways showed that the differential metabolic pathways between CTL and PLC groups were mainly involved in primary bile acid biosynthesis, phenylalanine metabolism, fructose and mannose metabolism, choline metabolism in cancer, cholesterol metabolism, and bile secretion, etc. CTL and JWXY groups’ metabolic pathways were mainly involved in primary bile acid biosynthesis, phenylalanine metabolism, fructose and mannose metabolism, fatty acid biosynthesis, cholesterol metabolism, and bile secretion.