RNA-seq and the western blot were performed on IPSC-CMs to explore the ARVC-related signaling pathway.<h4>Conclusion</h4>This is the first case report to describe an ARVC phenotype in patients possessing a novel <i>LAMA2 c.8842G</i> > <i>A</i> (<i>p.G2948S</i>) mutation. This evidence concerns the gene LAMA2 and arrhythmogenic right ventricular cardiomyopathy.