SIRT1 and liver failure: Seven differentially expressed ferroptosis-related genes (Hmox1, Epas1, Sirt1, Slc3a2, Jun, Plin2 and Zfp36) were obtained through the intersection of ferroptosis-related genes in the FerrDb database with DEGs in the GSE60088 dataset, and all of these genes were up-regulated in liver failure (Fig. 3A).