According to Zhu et al. (2019) these newly discovered ceRNA interaction axes could be an important targets for treating intervertebral disc degeneration, including Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/hsa_circRNA_102348-hsa-miR-185-5p-TGFB1/FOS,MALAT1-hsa-miR-155-5p-HIF1A, hsa_circRNA_102399-hsa-miR-302a-3p-HIF1A, MALAT1-hsa-miR-519d-3p-MAPK1, and hsa_circRNA_100086-hsa-miR-509-3p-MAPK1 ceRNA axes. The gene discussed is MAPK1; the disease is Intervertebral disk degeneration.