CSVD patients with lower IL-8 levels were associated with an increased risk of anxiety in males but not in females, and the adjusted OR with 95%CI were 3.94 (1.22–12.70, p = 0.022), 3.93 (1.22–12.62, p = 0.021) and 3.32 (1.14-9.61, p = 0.027) in Q1, Q2 and Q3 vs. Q4, respectively. The gene discussed is CXCL8; the disease is Anxiety.