Results from clinical research to define native humoral immunity against S. aureus in osteomyelitis patients also supports the hypothesis that passive immunization with anti-Gmd mAb may be an effective treatment (Gedbjerg et al., 2013; Oh et al., 2018; Kates et al., 2020; Owen et al., 2021). The gene discussed is GMDS; the disease is osteomyelitis.