Severe COVID‐19 patients have elevated levels of inflammatory cytokines, including IL‐2, IL‐4, IL‐6, IL‐7, TNF‐α, IL‐10, GM‐CSF, and IFN, which may be associated with CS, many of them regulate the immune response and inflammation via the JAK/STAT pathway (Figure 3).8, 93, 94. Here, CSF2 is linked to Cowden syndrome 1.