Activation of this signaling pathway promotes the secretion of multiple inflammatory factors, including vascular endothelial growth factor (VEGF), monocyte chemotactic protein‐1 (MCP‐1), IL‐8, and more IL‐6, leading to a systemic “cytokine storm.”108, 109 Dysregulation of the IL‐6 inflammatory pathway also promotes atherosclerosis and enhances vascular permeability, acting on cardiovascular disease in COVID‐CS, hypotension, and pulmonary dysfunction in ARDS.104, 110, 111. The gene discussed is VEGFA; the disease is cardiovascular disorder.