CD8A and Cowden syndrome 1: High viral titers and cytokine/chemokine responses recruit more innate immune cells (monocytes, macrophages, neutrophils, DCs, and NK cells) and activate adaptive immune cells (CD4+ and CD8+ T cells) from peripheral tissues, which cause hyperactivation of the immune system and massive inflammation and lead to an inflammatory CS.11, 39, 43, 44, 45