However, the analyses identified a missense variant in the gene PLG, which might represent an interesting candidate for protection against ACEi/ARB-induced angioedema, since it has previously been associated with lower plasma levels of plasminogen (Ma et al., 2014), a protein which is involved in the formation of bradykinin (de Maat et al., 2018). The gene discussed is PLG; the disease is angioedema.