PLG and hereditary angioedema: In HAE, disease-causing mutations have been reported in the genes SERPING1 (Ponard et al., 2020), F12 (Cichon et al., 2006; Dewald and Bork, 2006), ANGPT1 (Bafunno et al., 2018), PLG (Bork et al., 2018), and KNG1 (Bork et al., 2019).