Upregulation of USP1 is related to progression and poor prognosis such as, multiple myeloma (Das et al., 2017), and hepatocellular carcinoma (Zhao et al., 2020), and also mediated chemotherapy resistance (Sonego et al., 2019) (García-Santisteban et al., 2013). The gene discussed is USP1; the disease is AL amyloidosis.