After correcting for confounding variables (including age, sex, BMI, SBP, DBP, ALT, AST, sCr, smoking status, drinking status, and family history of diabetes), the results suggested that the TG/HDL-c ratio was still positively associated with incident diabetes in participants with diabetes (HR = 1.103, 95% CI: 1.020–1.193, P = 0.014). The gene discussed is GPT; the disease is diabetes mellitus.