As a highly conserved nuclease, TatD DNase domain containing 1 (TATDN1), a member of the TATD family, has been found upregulated in hepatocellular carcinoma (HCC) and cisplatin-resistant NSCLC (Shen et al., 2019; Wang et al., 2019). This evidence concerns the gene TATDN1 and hepatocellular carcinoma.