We combined single nucleotide polymorphism profiles with somatic mutation profiles of CRC and identified seven genomic instability-related AS events (PDHA1-88633-ES, KIAA1522-1632-AP, TATDN1-85088-ES, PRMT1-51042-ES, VEZT-23786-ES, AIG1-77972-AT, and PHF11-25891-AP) to construct our prognostic signature in the training set. The gene discussed is PHF11; the disease is colorectal carcinoma.