First, 17 genes were identified as clonal or private alterations in lymphatic metastasis; second, the alteration frequencies of TET2 (2% in P, 5% in LN) and ATR (3% in P, 8% in LN) were significantly higher in lymphatic metastasis than primary lesions, which considered as metastasis-related events. Here, ATR is linked to Lymphatic Metastasis.