UA could reduce the Aβ-induced tyrosine nitration of synaptophysin and the nitration and hyperphosphorylation of tau as a peroxynitrite scavenger (Tran et al., 2003; Zhang et al., 2006), and high levels of sUA could alleviate the effect of CSF Aβ42 and tau on cognitive decline (Ye et al., 2016). Here, MAPT is linked to Mental deterioration.