SYP and Mental deterioration: UA could reduce the Aβ-induced tyrosine nitration of synaptophysin and the nitration and hyperphosphorylation of tau as a peroxynitrite scavenger (Tran et al., 2003; Zhang et al., 2006), and high levels of sUA could alleviate the effect of CSF Aβ42 and tau on cognitive decline (Ye et al., 2016).