This effect also occurs in the Scn1a model following postnatal injection of tau-targeting antisense oligonucleotides (Shao et al., 2022), suggesting that antisense oligonucleotides may be a promising treatment avenue for children with Dravet syndrome. This evidence concerns the gene MAPT and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.