As is seen with GSK-3β, CDK5 overactivation is present in resected tissue from refractory epilepsy patients (Xi et al., 2009; Liu X. et al., 2017), and dysplastic cortical neurons in FCD patients express CDK5 aggregations (Sisodiya et al., 2002). The gene discussed is CDK5; the disease is fleck corneal dystrophy.