Temporal lobe epilepsy (TLE) is one of the most prevalent forms of focal epilepsy (Tellez-Zenteno and Hernandez-Ronquillo, 2012; Asadi-Pooya et al., 2017), and in the electrical amygdala kindling rodent model of TLE, tau-knockout mice do not differ from wild-type mice in seizure outcome following repeated kindling (Liu S. et al., 2017). Here, MAPT is linked to focal epilepsy.