Similarly, abnormal p-tau in the form of NFTs are also observed in the Epm2a–/– mouse model (Puri et al., 2009), which replicates many of the features of Lafora disease caused by EPM2A mutations, including laforin deficiency, neuronal degeneration, spontaneous epileptic activity, and the development of Lafora bodies (Ganesh et al., 2002). Here, MAPT is linked to Lafora disease.