Transcription factors such as cyclic-adenosine monophosphate (cAMP) response element-binding protein (CREB), nuclear factor kappa B (NF-κB), and nuclear factor erythroid 2-related factor 2 (Nrf2) play an important role in the development of depression, and they could also interact with other transcription factors. The gene discussed is CREB1; the disease is depressive disorder.