MAPT and early-onset autosomal dominant Alzheimer disease: The accumulation of filamentous tau aggregates is a pathological hallmark of tauopathies, including Alzheimer’s disease (AD), frontotemporal dementia (FTDP-17), Pick’s disease, and progressive supranuclear palsy (PSP) (Iqbal et al., 2010; Orr et al., 2017).