PICALM and Alzheimer disease: Ando et al. (2016) reported the co-localization of phosphorylated tau with PICALM in the brains of AD patients. BIN1 is known to be involved in clathrin-mediated endocytosis through its interaction with clathrin and dynamin (Doherty and McMahon, 2009). However, the role of BIN1 in AD pathology remains largely unclear. Significantly decreased levels of BIN1 were observed in the brains of late-onset AD patients (Holler et al., 2014). The knock-down of BIN1 is known to promote endocytosis of extracellular tau aggregates (Calafate et al., 2016).