PRKN and Parkinson disease: And then, in 2010, four outstanding studies revealed the molecule mechanism of PINK1/Parkin-mediated mitophagy and its pathogenic mechanisms in the pathogenesis of Parkinson’s disease (Geisler et al., 2010; Matsuda et al., 2010; Narendra et al., 2010; Vives-Bauza et al., 2010).