By further reading their publications, we can understand that Richard J. Youle mainly focused on the mechanisms of mitophagy (Youle and Narendra, 2011) and the roles of PINK1, Parkin, and mitochondrial fidelity in Parkinson’s Disease (Pickrell and Youle, 2015); Hao Zhou mainly focused on the role of mitophagy in cardiovascular disease, especially in cardiac microvascular ischemia/reperfusion injury (Zhou et al., 2018; Wang et al., 2020); Daniel J. Klionsky mainly focused on the selective mechanism during mitophagy (Kanki et al., 2009; Wang and Klionsky, 2011; Gatica et al., 2018). Here, PRKN is linked to cardiovascular disorder.