Moreover, among these characteristic species, levels of Cer(d15:1/25:2), Cer(d18:1/16:0), Cer(d18:1/24:0), Cer(d40:1), Cer(d41:1 + O), Cer(m34:0 + O), Cer(m38:2 + O) and PI(16:1) were negatively while levels of Cer(d32:4), CerG2GNAc1(d32:1), CerG2GNAc1(d36:1), CerG2GNAc1(d38:4), GM2(d34:5), GM3(t39:6), PC(18:0/16:0), PC(20:1e/18:2), PC(26:2e), PC(40:10), TG(18:1/18:2/22:4) and TG(20:0/18:1/18:1) were positively correlated with the scores of HAMA, HAMD and PANSS (Figure 3F), indicating those lipids in the plasma might be a combinational biomarker for women with MDD. The gene discussed is CBLN1; the disease is major depressive disorder.