In recent years, genome-wide association studies (GWAS) have highlighted the importance of FUT2 biology, and HBGA was found to serve as an attachment site for both intestinal flora and norovirus (NoV) and rotavirus (RV), identifying different polymorphisms of this gene resulting in distinct secretor statuses associated with the development of pathophysiological conditions between intestinal diseases (Maroni et al., 2015; Iliev and Cadwell, 2021; Tarris et al., 2021). The gene discussed is FUT2; the disease is intestinal disorder.