In this review, we aimed to provide a brief overview of the effect of FUT2 on intestinal diseases, link HBGA to intestinal flora and enterovirus through some hypotheses about the way HBGA mediates intestinal flora, and investigate whether the FUT2 gene can be used to infer susceptibility to intestinal diseases so that the prevention can be better personalized for individuals in different regions. Here, FUT2 is linked to intestinal disorder.