It can induce the activation of the MLCK-pMLC phosphorylation signaling pathway under various pathological conditions [such as hypoxia, lipopolysaccharide (LPS) stimulation, burn injuries, and inflammatory bowel disease (IBD), among others], leading to a decrease in the expression of the tight junction protein Zonula occludens protein 1 (ZO-1), disruption of intestinal mucosal barrier continuous distribution, and increase in the permeability of the intestinal mucosal barrier and damage of intestinal mucosal barrier function (Song et al., 2019). The gene discussed is TJP1; the disease is inflammatory bowel disease.