MYLK and inflammatory bowel disease: It can induce the activation of the MLCK-pMLC phosphorylation signaling pathway under various pathological conditions [such as hypoxia, lipopolysaccharide (LPS) stimulation, burn injuries, and inflammatory bowel disease (IBD), among others], leading to a decrease in the expression of the tight junction protein Zonula occludens protein 1 (ZO-1), disruption of intestinal mucosal barrier continuous distribution, and increase in the permeability of the intestinal mucosal barrier and damage of intestinal mucosal barrier function (Song et al., 2019).