Further, in vitro studies in the erythroleukemic cell line K562 and lymphoblastoid cell lines derived from patients with EPP and healthy controls showed a dose-dependent increase in aberrant FECH mRNA splicing under iron-depleted cell culture conditions that is more pronounced in the more common c.[315-48T] genotype (Barman-Aksözen et al., 2013). The gene discussed is FECH; the disease is autosomal erythropoietic protoporphyria.