Finally, as it can be seen in Figure 1E, the FECH gene is lower expressed in the cohort of EPP patients (822.1 ± 248.5 copies/μl) compared to the controls (1543.3 ± 718 copies/μlp <0.003), confirming the effect of the mutation on this gene, i.e., a premature termination codon at a position that leads to the degradation of the FECH mRNA derived from this allele via the nonsense-mediated decay mechanism. Here, FECH is linked to autosomal erythropoietic protoporphyria.