One of the known ligands of integrin αvβ1 is fibronectin (Koths et al., 1993), which is a key glycoprotein in the cancer‐related extracellular matrix (Zhang et al., 1993) and can bind to integrins via the RGD motif recognition to mediate cell adhesion (Saad et al., 2002). This evidence concerns the gene ART4 and cancer.