Treatment with dabigatran (150 mg/kg/day) alone and in combination with either PAR‐1 agonist TFLLR‐NH2 (dosed at 0.25 μmol/kg/day and 0.50 μmol/kg/day) or inhibitor SCH79797 (dosed at 1 mg/kg/day and 3 mg/kg/day) resulted in gradual development of hematuria in 5/6NE rats (Figure 2a,b). The gene discussed is F2R; the disease is Hematuria.