We had demonstrated that inhibition of PAR‐1 by SCH79797 results in glomerular hemorrhage and acute kidney injury in 5/6 nephrectomy rats (5/6NE), effects similar to those of direct thrombin inhibitor dabigatran and mimicking human anticoagulant related nephropathy (Ryan et al., 2014). This evidence concerns the gene F2R and Nephropathy.